Pub. Date : 2012 Apr-Jun
PMID : 22743729
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In heart recipients, TGF-beta genetic polymorphisms were associated with tacrolimus-induced nephrotoxicity. | Tacrolimus | transforming growth factor beta 1 | Homo sapiens |
| 2 | CONCLUSIONS: Limited evidence suggests that variation in genes involved in pharmacokinetics (ABCB1 and CYP3A5) and pharmacodynamics (TGF-beta, CYP2C8, ACE, CCR5) of tacrolimus may impact a transplant recipients" risk to develop tacrolimus-induced nephrotoxicity across different transplant organ groups. | Tacrolimus | transforming growth factor beta 1 | Homo sapiens |
| 3 | CONCLUSIONS: Limited evidence suggests that variation in genes involved in pharmacokinetics (ABCB1 and CYP3A5) and pharmacodynamics (TGF-beta, CYP2C8, ACE, CCR5) of tacrolimus may impact a transplant recipients" risk to develop tacrolimus-induced nephrotoxicity across different transplant organ groups. | Tacrolimus | transforming growth factor beta 1 | Homo sapiens |