Pub. Date : 2012 Jul 26
PMID : 22742452
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We screened a large database in silico to find alternative molecules and predicted d-myo-inositol 3,4,5,6-tetrakisphosphate (TMI) to strongly interact with antithrombin. | 4-tolyl isocyanate | serpin family C member 1 | Homo sapiens |
| 2 | Functional studies, fluorescence analysis, and citrullination experiments revealed that TMI induced a partial activation of antithrombin that facilitated the interaction with heparin and low affinity heparins. | 4-tolyl isocyanate | serpin family C member 1 | Homo sapiens |
| 3 | TMI improved antithrombin inhibitory function of plasma from homozygous patients with antithrombin deficiency with a heparin binding defect and also in a model with endothelial cells. | 4-tolyl isocyanate | serpin family C member 1 | Homo sapiens |
| 4 | TMI improved antithrombin inhibitory function of plasma from homozygous patients with antithrombin deficiency with a heparin binding defect and also in a model with endothelial cells. | 4-tolyl isocyanate | serpin family C member 1 | Homo sapiens |