Title : DBC1 phosphorylation by ATM/ATR inhibits SIRT1 deacetylase in response to DNA damage.

Pub. Date : 2012 Oct

PMID : 22735644






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Human DBC1 (deleted in breast cancer-1; KIAA1967) is a nuclear protein that, in response to DNA damage, competitively inhibits the NAD(+)-dependent deacetylase SIRT1, a regulator of p53 apoptotic functions in response to genotoxic stress. NAD tumor protein p53 Homo sapiens