Pub. Date : 2012 Jun 27
PMID : 22734582
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | METHODS: Peripheral blood mononuclear cells (PBMCs) from SLE subjects treated or not with HCQ and from healthy controls were stimulated with the TLR-9 agonist, CpG oligodeoxynucleotides (CpG-A ODN)-2216, and the TLR-7 agonist, imiquimod. | Hydroxychloroquine | toll like receptor 9 | Homo sapiens |
| 2 | In almost all cases, these subjects were being treated with HCQ (HCQ vs. no HCQ: impaired TLR-9/IFN-alpha, P = 0.0003; impaired TLR-7/IFN-alpha, P = 0.07; impaired TLR-9/TNF-alpha, P < 0.009; impaired TLR-7/TNF-alpha, P < 0.01). | Hydroxychloroquine | toll like receptor 9 | Homo sapiens |
| 3 | In almost all cases, these subjects were being treated with HCQ (HCQ vs. no HCQ: impaired TLR-9/IFN-alpha, P = 0.0003; impaired TLR-7/IFN-alpha, P = 0.07; impaired TLR-9/TNF-alpha, P < 0.009; impaired TLR-7/TNF-alpha, P < 0.01). | Hydroxychloroquine | toll like receptor 9 | Homo sapiens |
| 4 | In almost all cases, these subjects were being treated with HCQ (HCQ vs. no HCQ: impaired TLR-9/IFN-alpha, P = 0.0003; impaired TLR-7/IFN-alpha, P = 0.07; impaired TLR-9/TNF-alpha, P < 0.009; impaired TLR-7/TNF-alpha, P < 0.01). | Hydroxychloroquine | toll like receptor 9 | Homo sapiens |
| 5 | In almost all cases, these subjects were being treated with HCQ (HCQ vs. no HCQ: impaired TLR-9/IFN-alpha, P = 0.0003; impaired TLR-7/IFN-alpha, P = 0.07; impaired TLR-9/TNF-alpha, P < 0.009; impaired TLR-7/TNF-alpha, P < 0.01). | Hydroxychloroquine | toll like receptor 9 | Homo sapiens |
| 6 | In almost all cases, these subjects were being treated with HCQ (HCQ vs. no HCQ: impaired TLR-9/IFN-alpha, P = 0.0003; impaired TLR-7/IFN-alpha, P = 0.07; impaired TLR-9/TNF-alpha, P < 0.009; impaired TLR-7/TNF-alpha, P < 0.01). | Hydroxychloroquine | toll like receptor 9 | Homo sapiens |
| 7 | In almost all cases, these subjects were being treated with HCQ (HCQ vs. no HCQ: impaired TLR-9/IFN-alpha, P = 0.0003; impaired TLR-7/IFN-alpha, P = 0.07; impaired TLR-9/TNF-alpha, P < 0.009; impaired TLR-7/TNF-alpha, P < 0.01). | Hydroxychloroquine | toll like receptor 9 | Homo sapiens |
| 8 | CONCLUSIONS: Treatment with HCQ is associated with impaired ability of pDCs from subjects with SLE to produce IFN-alpha and TNF-alpha upon stimulation with TLR-9 and TLR-7 agonists. | Hydroxychloroquine | toll like receptor 9 | Homo sapiens |