Pub. Date : 2012 Sep 1
PMID : 22727936
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of sphingosine kinase 1 enhances cytotoxicity, ceramide levels and ROS formation in liver cancer cells treated with selenite. | Selenious Acid | sphingosine kinase 1 | Homo sapiens |
| 2 | The sphingosine kinase 1 (SK1) inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole (SK1-II) sensitized the cells to the cytotoxic effects of selenite. | Selenious Acid | sphingosine kinase 1 | Homo sapiens |
| 3 | The sphingosine kinase 1 (SK1) inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole (SK1-II) sensitized the cells to the cytotoxic effects of selenite. | Selenious Acid | sphingosine kinase 1 | Homo sapiens |
| 4 | The sphingosine kinase 1 (SK1) inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole (SK1-II) sensitized the cells to the cytotoxic effects of selenite. | Selenious Acid | sphingosine kinase 1 | Homo sapiens |
| 5 | Preincubation with 10 muM of SK1-II prior to treatment with 10 muM of selenite caused induction of apoptosis and gave rise to a 2.5-fold increase in C14-, C16-, C18- and C18:1- ceramides. | Selenious Acid | sphingosine kinase 1 | Homo sapiens |
| 6 | The formation of reactive oxygen species (ROS) after treatment with 10 muM of selenite was maximally enhanced by 1 muM of SK1-II. | Selenious Acid | sphingosine kinase 1 | Homo sapiens |