Title : Peptide-specific transfer of N-acetylgalactosamine to O-linked glycans by the glycosyltransferases β1,4-N-acetylgalactosaminyl transferase 3 (β4GalNAc-T3) and β4GalNAc-T4.

Pub. Date : 2012 Aug 17

PMID : 22722940






2 Functional Relationships(s)
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1 We characterized how two beta1,4-N-acetylgalactosaminyltransferases, beta4GalNAc-T3 and beta4GalNAc-T4, require the presence of both the peptide recognition motif and the N-linked oligosaccharide acceptors to transfer GalNAc in beta1,4-linkage to GlcNAc in vivo and in vitro. N-acetylgalactosaminuronic acid beta-1,4-N-acetyl-galactosaminyltransferase 4 Homo sapiens
2 We now show that beta4GalNAc-T3 and beta4GalNAc-T4 are able to utilize the same peptide motif to selectively add GalNAc to beta1,6-linked GlcNAc in core 2 O-linked oligosaccharide structures to form Galbeta1,3(GalNAcbeta1,4GlcNAcbeta1,6)GalNAcalphaSer/Thr. N-acetylgalactosaminuronic acid beta-1,4-N-acetyl-galactosaminyltransferase 4 Homo sapiens