Pub. Date : 2013 Jun
PMID : 22721392
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The role of autophagic cell death and apoptosis in irinotecan-treated p53 null colon cancer cells. | Irinotecan | tumor protein p53 | Homo sapiens |
| 2 | The roles of autophagic cell death and apoptosis induced by topoisomerase inhibitor irinotecan in colon cancer cells with deleted p53 were investigated during 48 h. We report that irinotecan-dependent cytotoxicity and proapoptotic activity were reduced in the present model while autophagy levels significantly increased. | Irinotecan | tumor protein p53 | Homo sapiens |
| 3 | These results suggest that different modes of cell death in p53 null colon cancer cells treated with cytostatics (irinotecan) may be activated simultaneously. | Irinotecan | tumor protein p53 | Homo sapiens |