Title : Structure of an engineered β-lactamase maltose binding protein fusion protein: insights into heterotropic allosteric regulation.

Pub. Date : 2012

PMID : 22720063






2 Functional Relationships(s)
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1 Mutagenesis and molecular modeling of an intact TEM-1 domain near MBP within the RG13 framework indicated a close surface proximity of the two domains with maltose switching being critically dependent on MBP linker anchoring residues and linker length. Maltose CD248 molecule Homo sapiens
2 Maltose activation and zinc inhibition of RG13 are hypothesized to have opposite effects on productive relaxation of the TEM-1 beta3 linker region via steric and/or linker juxtapositioning mechanisms. Maltose CD248 molecule Homo sapiens