Pub. Date : 2012 Aug
PMID : 22713701
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Polymorphic glucuronidation of olanzapine by uridine diphosphate glucuronosyltransferase 1A4 (UGT1A4) was investigated retrospectively in patient samples taken for routine therapeutic drug monitoring (TDM) and in recombinant metabolic systems in vitro. | Olanzapine | UDP glucuronosyltransferase family 1 member A4 | Homo sapiens |
| 2 | UGT1A4*3 encodes significantly increased glucuronidation of olanzapine in patients on maintenance treatment and in recombinant systems. | Olanzapine | UDP glucuronosyltransferase family 1 member A4 | Homo sapiens |
| 3 | Polymorphic glucuronidation of olanzapine by uridine diphosphate glucuronosyltransferase 1A4 (UGT1A4) was investigated retrospectively in patient samples taken for routine therapeutic drug monitoring (TDM) and in recombinant metabolic systems in vitro. | Olanzapine | UDP glucuronosyltransferase family 1 member A4 | Homo sapiens |
| 4 | This finding was in line with the significant increases in glucuronidation activity of olanzapine observed with recombinant UGT1A4.3 (Val-48) as compared with UGT1A4.1 (Leu-48) (1.3-fold difference, P < 0.001). | Olanzapine | UDP glucuronosyltransferase family 1 member A4 | Homo sapiens |
| 5 | This finding was in line with the significant increases in glucuronidation activity of olanzapine observed with recombinant UGT1A4.3 (Val-48) as compared with UGT1A4.1 (Leu-48) (1.3-fold difference, P < 0.001). | Olanzapine | UDP glucuronosyltransferase family 1 member A4 | Homo sapiens |