Title : EGCG targeting efficacy of NF-κB downstream gene products is dictated by the monocytic/macrophagic differentiation status of promyelocytic leukemia cells.

Pub. Date : 2012 Dec

PMID : 22707304






2 Functional Relationships(s)
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1 NF-kappaB-mediated signaling during HL-60 macrophage differentiation was reversed by EGCG, in part through reduced IkappaB phosphorylation and led to the inhibition of moderately to highly expressed NF-kappaB gene targets among which the matrix metalloproteinase (MMP)-9 and the cyclooxygenase (COX)-2. epigallocatechin gallate mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 In contrast, EGCG exhibited low efficacy in reversing NF-kappaB-regulated genes and showed selective antagonism toward COX-2 expression while that of MMP-9 remained high in terminally differentiated macrophages. epigallocatechin gallate mitochondrially encoded cytochrome c oxidase II Homo sapiens