Title : [Effect of tunicamycin combined with cisplatin on proliferation and apoptosis of human nasopharyngeal carcinoma cells in vitro].

Pub. Date : 2012 Jun

PMID : 22699051






2 Functional Relationships(s)
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1 The expressions of Bax, Bcl-2, and GRP78 in cells treated with 3 micromol/L tunicamycin with or without 6.00 micromol/L cisplatin were measured with Western blotting. Tunicamycin heat shock protein family A (Hsp70) member 5 Homo sapiens
2 Compared with tunicamycin and cisplatin alone, the combined treatment significantly increased Bax expression and decreased Bcl-2 expression in the cells; tunicamycin up-regulated the expression of GRP-78 and enhanced the activity of caspase-3. Tunicamycin heat shock protein family A (Hsp70) member 5 Homo sapiens