Pub. Date : 2012 Jul
PMID : 22693311
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Unfortunately, folic acid and folate-linked drugs bind equally well to both major isoforms of the FR-that is, FR-alpha, which is primarily expressed on malignant cells, and FR-beta, which is upregulated on activated monocytes and macrophages. | Folic Acid | rabaptin, RAB GTPase binding effector protein 2 | Mus musculus |
| 2 | Unfortunately, folic acid and folate-linked drugs bind equally well to both major isoforms of the FR-that is, FR-alpha, which is primarily expressed on malignant cells, and FR-beta, which is upregulated on activated monocytes and macrophages. | Folic Acid | rabaptin, RAB GTPase binding effector protein 2 | Mus musculus |
| 3 | In an effort to develop a targeting ligand that can selectively deliver attached imaging and therapeutic agents to tumor cells, we constructed a reduced and alkylated form of folic acid, N(5), N(10)-dimethyl tetrahydrofolate (DMTHF) that exhibits selectivity for FR-alpha. | Folic Acid | rabaptin, RAB GTPase binding effector protein 2 | Mus musculus |