Title : Celecoxib synergizes human pancreatic ductal adenocarcinoma cells to sorafenib-induced growth inhibition.

Pub. Date : 2012 May-Jun

PMID : 22687377






7 Functional Relationships(s)
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1 These changes were accompanied by a significant reduction of p21(WAF1/Cip1) levels, where celecoxib sensitized the cells to sorafenib-mediated p21(WAF1/Cip1) suppression. Sorafenib cyclin dependent kinase inhibitor 1A Homo sapiens
2 These changes were accompanied by a significant reduction of p21(WAF1/Cip1) levels, where celecoxib sensitized the cells to sorafenib-mediated p21(WAF1/Cip1) suppression. Sorafenib cyclin dependent kinase inhibitor 1A Homo sapiens
3 These changes were accompanied by a significant reduction of p21(WAF1/Cip1) levels, where celecoxib sensitized the cells to sorafenib-mediated p21(WAF1/Cip1) suppression. Sorafenib cyclin dependent kinase inhibitor 1A Homo sapiens
4 These changes were accompanied by a significant reduction of p21(WAF1/Cip1) levels, where celecoxib sensitized the cells to sorafenib-mediated p21(WAF1/Cip1) suppression. Sorafenib cyclin dependent kinase inhibitor 1A Homo sapiens
5 CONCLUSION: These results suggest that combined treatment with sorafenib and celecoxib synergistically induce growth inhibition and apoptosis in pancreatic adenocarcinoma cells through a process involving p21(WAF1/Cip1) suppression. Sorafenib cyclin dependent kinase inhibitor 1A Homo sapiens
6 CONCLUSION: These results suggest that combined treatment with sorafenib and celecoxib synergistically induce growth inhibition and apoptosis in pancreatic adenocarcinoma cells through a process involving p21(WAF1/Cip1) suppression. Sorafenib cyclin dependent kinase inhibitor 1A Homo sapiens
7 CONCLUSION: These results suggest that combined treatment with sorafenib and celecoxib synergistically induce growth inhibition and apoptosis in pancreatic adenocarcinoma cells through a process involving p21(WAF1/Cip1) suppression. Sorafenib cyclin dependent kinase inhibitor 1A Homo sapiens