Title : Androgen-independent prostate cancer cells circumvent EGFR inhibition by overexpression of alternative HER receptors and ligands.

Pub. Date : 2012 Sep

PMID : 22684500






1 Functional Relationships(s)
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1 In the erlotinib-resistant DUErR cells, the expression of HER2 and HER3 was increased at mRNA and protein levels together with neuregulin-1, leading to enhanced HER3 phosphorylation and the activation of the downstream PI3K/Akt survival pathway. Erlotinib Hydrochloride neuregulin 1 Homo sapiens