Title : Estradiol acutely suppresses inhibition in the hippocampus through a sex-specific endocannabinoid and mGluR-dependent mechanism.

Pub. Date : 2012 Jun 7

PMID : 22681685






1 Functional Relationships(s)
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Protein Name
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1 E2 acts through the alpha form of the estrogen receptor to stimulate postsynaptic mGluR1-dependent mobilization of the endocannabinoid anandamide, which retrogradely suppresses GABA release from CB1 receptor-containing inhibitory presynaptic boutons. Endocannabinoids glutamate metabotropic receptor 1 Homo sapiens