Title : [Structure-functional organization of eukaryotic high-affinity copper importer CTR1 determines its ability to transport copper, silver and cisplatin].

Pub. Date : 2012 Mar-Apr

PMID : 22670529






2 Functional Relationships(s)
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1 At present there is no rational explanation how CTR1 can transfer platinum group, which is different by coordination properties from highly similar Cu(I) and Ag(I). Platinum solute carrier family 31, member 1 Mus musculus
2 Basing on structural and functional peculiarities of N-terminal part of CTR1 a hypothesis of coupled transport of copper and cisplatin has been suggested, which avoids the disagreement between CTR1-mediated cisplatin transport in vitro, and irreversible binding of platinum to Met-rich peptides. Platinum solute carrier family 31, member 1 Mus musculus