Title : Ligand binding promotes CDK-dependent phosphorylation of ER-alpha on hinge serine 294 but inhibits ligand-independent phosphorylation of serine 305.

Pub. Date : 2012 Aug

PMID : 22669764






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Ligand binding promotes CDK-dependent phosphorylation of ER-alpha on hinge serine 294 but inhibits ligand-independent phosphorylation of serine 305. Serine estrogen receptor 1 Homo sapiens
2 Recent attention has turned to the poorly understood ERalpha hinge domain, as phosphorylation at serine 305 (Ser305) associates with poor clinical outcome and endocrine resistance. Serine estrogen receptor 1 Homo sapiens