Title : LRRK2 kinase activity mediates toxic interactions between genetic mutation and oxidative stress in a Drosophila model: suppression by curcumin.

Pub. Date : 2012 Sep

PMID : 22668778






1 Functional Relationships(s)
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1 Treatment with a LRRK2 kinase inhibitor (GW5074) or an anti-oxidant (curcumin) significantly suppressed these PD-like phenotypes in flies. 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone Leucine-rich repeat kinase Drosophila melanogaster