Pub. Date : 2012 Aug
PMID : 22665525
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | The topoisomerase I inhibitor irinotecan is used to treat advanced colorectal cancer and has been shown to have p53-independent anticancer activity. | Irinotecan | tumor protein p53 | Homo sapiens |
2 | The aim of this study was to identify the p53-independent signaling mechanisms activated by irinotecan. | Irinotecan | tumor protein p53 | Homo sapiens |
3 | Transcriptional profiling of isogenic HCT116 p53 wild-type and p53 null cells was carried out following treatment with the active metabolite of irinotecan, SN38. | Irinotecan | tumor protein p53 | Homo sapiens |
4 | Transcriptional profiling of isogenic HCT116 p53 wild-type and p53 null cells was carried out following treatment with the active metabolite of irinotecan, SN38. | Irinotecan | tumor protein p53 | Homo sapiens |