Title : Regulation of BACE1 by miR-29a/b in a cellular model of Spinocerebellar Ataxia 17.

Pub. Date : 2012 Jun

PMID : 22664922






3 Functional Relationships(s)
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Protein Name
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1 The expansion of a polyglutamine repeat in the TATA binding protein (TBP) causes a neurodegenerative disease, Spinocerebellar Ataxia 17 (SCA17). polyglutamine TATA-box binding protein Homo sapiens
2 The expansion of a polyglutamine repeat in the TATA binding protein (TBP) causes a neurodegenerative disease, Spinocerebellar Ataxia 17 (SCA17). polyglutamine TATA-box binding protein Homo sapiens
3 Here, we used a cellular model of SCA17 where we expressed TBP with 16 (normal) or 59 (pathogenic) polyglutamines and found differential expression of several microRNAs. polyglutamine TATA-box binding protein Homo sapiens