Pub. Date : 2011
PMID : 22654841
8 Functional Relationships(s)Download |
||||||
Sentence | Compound Name | Protein Name | Organism |
|||
| 1 | Estradiol plays a pivotal role in the control of gonadotropin-releasing hormone (GnRH) neuronal function and female reproduction. | Estradiol | gonadotropin releasing hormone 1 | Mus musculus | ||
| 2 | Estradiol plays a pivotal role in the control of gonadotropin-releasing hormone (GnRH) neuronal function and female reproduction. | Estradiol | gonadotropin releasing hormone 1 | Mus musculus | ||
| 3 | While positive and negative feedback actions of estradiol that enhance and suppress release of GnRH and LH are primarily mediated through estrogen receptor alpha located in interneurons, a series of recent studies in our laboratory indicate that rapid excitatory actions of estradiol also directly modify GnRH neuronal activity. | Estradiol | gonadotropin releasing hormone 1 | Mus musculus | ||
| 4 | While positive and negative feedback actions of estradiol that enhance and suppress release of GnRH and LH are primarily mediated through estrogen receptor alpha located in interneurons, a series of recent studies in our laboratory indicate that rapid excitatory actions of estradiol also directly modify GnRH neuronal activity. | Estradiol | gonadotropin releasing hormone 1 | Mus musculus | ||
| 5 | While positive and negative feedback actions of estradiol that enhance and suppress release of GnRH and LH are primarily mediated through estrogen receptor alpha located in interneurons, a series of recent studies in our laboratory indicate that rapid excitatory actions of estradiol also directly modify GnRH neuronal activity. | Estradiol | gonadotropin releasing hormone 1 | Mus musculus | ||
| 6 | We observed this phenomenon in cultured primate GnRH neurons, but similar rapid direct actions of estradiol are also described in cultured GnRH neurons and green fluorescent protein-labeled GnRH neurons of mice. | Estradiol | gonadotropin releasing hormone 1 | Mus musculus | ||
| 7 | We observed this phenomenon in cultured primate GnRH neurons, but similar rapid direct actions of estradiol are also described in cultured GnRH neurons and green fluorescent protein-labeled GnRH neurons of mice. | Estradiol | gonadotropin releasing hormone 1 | Mus musculus | ||
| 8 | Importantly, rapid direct action of estradiol in GnRH neurons is mediated through membrane or membrane associated receptors, such as GPR30, STX-sensitive receptors, and ERbeta. | Estradiol | gonadotropin releasing hormone 1 | Mus musculus | ||