Pub. Date : 2012 Jul 6
PMID : 22645136
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Here, we identified a BRC repeat variant, named BRCv, in the RECQL5 helicase, which possesses anti-recombinase activity in vitro and suppresses HR and promotes cellular resistance to camptothecin-induced replication stress in vivo. | Camptothecin | RecQ like helicase 5 | Homo sapiens |
2 | Mutations of either motif compromised functions of RECQL5, including association with RAD51, inhibition of RAD51-mediated D-loop formation, suppression of sister chromatid exchange, and resistance to camptothecin-induced replication stress. | Camptothecin | RecQ like helicase 5 | Homo sapiens |