Title : The naturally occurring aliphatic isothiocyanates sulforaphane and erucin are weak agonists but potent non-competitive antagonists of the aryl hydrocarbon receptor.

Pub. Date : 2012 Oct

PMID : 22643862






3 Functional Relationships(s)
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1 It is demonstrated in this paper that the isothiocyanates R,S-sulforaphane and erucin are non-competitive antagonists of the aryl hydrocarbon (Ah) receptor. sulforaphane aryl hydrocarbon receptor Rattus norvegicus
2 In further studies, it was demonstrated that R,S-sulforaphane could both prevent the interaction of and displace already bound benzo[a]pyrene from the Ah receptor, but no concentration dependency was observed with respect to the isothiocyanate. sulforaphane aryl hydrocarbon receptor Rattus norvegicus
3 Of the two isomers of R,S-sulforaphane, the naturally occurring R-isomer was more effective than the S-isomer in antagonizing the activation of the Ah receptor by benzo[a]pyrene. sulforaphane aryl hydrocarbon receptor Rattus norvegicus