Pub. Date : 2012 Jul 13
PMID : 22637474
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mutational analyses have established that an interaction of the carboxylate of AA with Arg-120 is required for high affinity binding by COX-1 but not COX-2, suggesting that hydrophobic interactions between the omega-end of substrates and cyclooxygenase channel residues play a significant role in COX-2-mediated oxygenation. | Arginine | cytochrome c oxidase II, mitochondrial | Mus musculus |
| 2 | We used structure-function analyses to investigate the role that Arg-120 and residues lining the hydrophobic groove play in the binding and oxygenation of substrates by murine (mu) COX-2. | Arginine | cytochrome c oxidase II, mitochondrial | Mus musculus |
| 3 | Overall, these findings implicate Arg-120 and hydrophobic groove residues as determinants that govern proper alignment of the bisallylic carbon below Tyr-385 for catalysis in COX-2 and confirm nuances between COX isoforms that explain substrate promiscuity. | Arginine | cytochrome c oxidase II, mitochondrial | Mus musculus |