Title : Activation of toll-like receptor 2 prevents suppression of T-cell interferon γ production by modulating p38/extracellular signal-regulated kinase pathways following alcohol and burn injury.

Pub. Date : 2012 Sep 7

PMID : 22634720






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We have shown previously that acute alcohol/ethanol (EtOH) intoxication combined with burn injury suppresses mesenteric lymph node (MLN) T-cell interleukin-2 (IL-2) and interferon gamma (IFN-gamma) production. Ethanol interferon gamma Mus musculus
2 We have shown previously that acute alcohol/ethanol (EtOH) intoxication combined with burn injury suppresses mesenteric lymph node (MLN) T-cell interleukin-2 (IL-2) and interferon gamma (IFN-gamma) production. Ethanol interferon gamma Mus musculus
3 Together, our findings suggest that TLR2 directly modulates T-cell IFN-gamma production following EtOH and burn injury, independent of antigen-presenting cells. Ethanol interferon gamma Mus musculus
4 Furthermore, we demonstrated that MyD88/TIRAP-dependent p38/ERK activation is critical to TLR2-mediated T-cell IFN-gamma release following EtOH and burn injury. Ethanol interferon gamma Mus musculus