Title : The aryl hydrocarbon receptor ligands 2,3,7,8-tetrachlorodibenzo-p-dioxin and 3-methylcholanthrene regulate distinct genetic networks.

Pub. Date : 2012 Oct 15

PMID : 22634562






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Like DES, 3-MC induced a number of ER-regulated genes and lead to recruitment of ERalpha to the promoters of such genes. Methylcholanthrene estrogen receptor 1 Homo sapiens
2 Interestingly, in contrast to DES, the estrogenic effects exerted by 3-MC were exclusively observed in ERalpha, but not in ERbeta-expressing cells, suggesting ER isoform selectivity of 3-MC-derived metabolites. Methylcholanthrene estrogen receptor 1 Homo sapiens