Title : Tetraspanin CD37 directly mediates transduction of survival and apoptotic signals.

Pub. Date : 2012 May 15

PMID : 22624718






1 Functional Relationships(s)
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1 Moreover, we have identified two tyrosine residues with opposing regulatory functions: one lies in the N-terminal domain of CD37 in a predicted "ITIM-like" motif and mediates SHP1-dependent death, whereas the second lies in a predicted "ITAM motif" in the C-terminal domain of CD37 and counteracts death signals by mediating phosphatidylinositol 3-kinase-dependent survival. Tyrosine nuclear receptor subfamily 0 group B member 2 Homo sapiens