Title : Antidiabetic properties of berberine: from cellular pharmacology to clinical effects.

Pub. Date : 2012 Apr

PMID : 22615079






1 Functional Relationships(s)
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1 In glucose-consuming tissues, such as adipose, or liver or muscle cells, berberine affects both GLUT-4 and retinol-binding protein-4 in favor of glucose uptake into cells; stimulates glycolysis by AMPK activation; and has effects on the peroxisome proliferator-activated receptor gamma molecular targets and on the phosphorylation of insulin receptor substrate-1, finally resulting in decreased insulin resistance. Glucose retinol binding protein 4 Homo sapiens