Pub. Date : 2012 Aug 1
PMID : 22592407
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Polyamines regulate intestinal epithelial restitution through TRPC1-mediated Ca2+ signaling by differentially modulating STIM1 and STIM2. | Polyamines | transient receptor potential cation channel subfamily C member 1 | Homo sapiens |
| 2 | Here, we show that polyamines regulate intestinal epithelial restitution through TRPC1-mediated Ca(2+) signaling by altering the ratio of STIM1 to STIM2. | Polyamines | transient receptor potential cation channel subfamily C member 1 | Homo sapiens |
| 3 | Induced STIM1/TRPC1 association by increasing polyamines enhanced Ca(2+) influx and stimulated epithelial restitution, while decreased formation of the STIM1/TRPC1 complex by polyamine depletion decreased Ca(2+) influx and repressed cell migration. | Polyamines | transient receptor potential cation channel subfamily C member 1 | Homo sapiens |
| 4 | Induced STIM1/TRPC1 association by increasing polyamines enhanced Ca(2+) influx and stimulated epithelial restitution, while decreased formation of the STIM1/TRPC1 complex by polyamine depletion decreased Ca(2+) influx and repressed cell migration. | Polyamines | transient receptor potential cation channel subfamily C member 1 | Homo sapiens |
| 5 | These results indicate that polyamines differentially modulate cellular STIM1 and STIM2 levels in IECs, in turn controlling TRPC1-mediated Ca(2+) signaling and influencing cell migration after wounding. | Polyamines | transient receptor potential cation channel subfamily C member 1 | Homo sapiens |