Title : Investigation of sanguinarine and chelerythrine effects on LPS-induced inflammatory gene expression in THP-1 cell line.

Pub. Date : 2012 Jul 15

PMID : 22592163






2 Functional Relationships(s)
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1 Two hours after LPS stimulation, cells influenced by sanguinarine and chelerythrine significantly declined the CCL-2 expression by a factors of 3.5 (p<0.001) and 1.9 (p<0.01); for those treated with prednisone the factor was 5.3 (p<0.001). sanguinarine C-C motif chemokine ligand 2 Homo sapiens
2 Sanguinarine decreased gene expression of CCL-2 and IL-6 more than chelerythrine and its effect was quite similar to prednisone. sanguinarine C-C motif chemokine ligand 2 Homo sapiens