Title : Pharmacogenetics meets metabolomics: discovery of tryptophan as a new endogenous OCT2 substrate related to metformin disposition.

Pub. Date : 2012

PMID : 22590580






1 Functional Relationships(s)
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1 An inhibition assay demonstrated the inhibitory effect of tryptophan on the uptake of 1-methyl-4-phenyl pyrinidium in a concentration dependent manner and subsequent uptake experiment revealed differential tryptophan-uptake rate in the oocytes expressing OCT2 reference and variant (808G>T). 1-methyl-4-phenyl pyrinidium solute carrier family 22 member 2 Homo sapiens