Title : Protein kinase C-δ (PKC-δ) and PKC-α mediate Ca(2+)-dependent increases in CNP mRNA in human vascular cells.

Pub. Date : 2012 Sep-Oct

PMID : 22583821






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 CNP mRNA is up-regulated in human vascular smooth muscle cells (SMC) by PDGF-BB via a protein kinase C (PKC)-dependent pathways, and by general PKC activation with phorbol myristate acetate (PMA). Tetradecanoylphorbol Acetate natriuretic peptide C Homo sapiens
2 CNP mRNA is up-regulated in human vascular smooth muscle cells (SMC) by PDGF-BB via a protein kinase C (PKC)-dependent pathways, and by general PKC activation with phorbol myristate acetate (PMA). Tetradecanoylphorbol Acetate natriuretic peptide C Homo sapiens
3 A 8-10-fold greater PMA-induced increase in CNP transcript in SMC than in HAEC suggests that smooth muscle cells could be selectively targeted for CNP up-regulation by PKC-alpha- and PKC-delta-activators. Tetradecanoylphorbol Acetate natriuretic peptide C Homo sapiens
4 A 8-10-fold greater PMA-induced increase in CNP transcript in SMC than in HAEC suggests that smooth muscle cells could be selectively targeted for CNP up-regulation by PKC-alpha- and PKC-delta-activators. Tetradecanoylphorbol Acetate natriuretic peptide C Homo sapiens