Pub. Date : 2013 Mar 28
PMID : 22580602
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Alteration of MRP3, MRP4, hCNT1 and hCNT3 expression was observed in MUC4-KD cells, but only hCNT1 alteration was correlated to MUC4 expression and sensitivity to gemcitabine. | gemcitabine | solute carrier family 28 member 1 | Homo sapiens |
| 2 | This work describes a new mechanism of PC cell resistance to gemcitabine, in which the MUC4 mucin negatively regulates the hCNT1 transporter expression via the NF-kappaB pathway. | gemcitabine | solute carrier family 28 member 1 | Homo sapiens |
| 3 | Altogether, these data point out to MUC4 and hCNT1 as potential targets to ameliorate the response of pancreatic tumors to gemcitabine treatment. | gemcitabine | solute carrier family 28 member 1 | Homo sapiens |