Title : Naltrexone modification of drinking effects in a subacute treatment and bar-lab paradigm: influence of OPRM1 and dopamine transporter (SLC6A3) genes.

Pub. Date : 2012 Nov

PMID : 22551036






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The opioid receptor (OPRM1) single nucleotide polymorphism (SNP) asn40asp has been shown to alter alcohol and naltrexone response in animals and humans. Alcohols opioid receptor mu 1 Homo sapiens
2 OPRM1 asn40 homozygotes (p = 0.028) and DAT 9 VNTR carriers (p = 0.032) had more stimulation to alcohol after the priming drink. Alcohols opioid receptor mu 1 Homo sapiens
3 However, although exploratory and in need of replication, it introduces the possibility that epistasis between the OPRM1 gene and DAT gene might need to be taken into account when examining differential genetic response to alcohol or medication treatment, especially in early-stage alcoholics. Alcohols opioid receptor mu 1 Homo sapiens