Title : Differential regulation of two glucose transporters by chronic growth hormone treatment of cultured 3T3-F442A adipose cells.

Pub. Date : 1990 Dec 15

PMID : 2254335






3 Functional Relationships(s)
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1 3-O-Methyl-D-glucose uptake was inhibited to an extent similar to that of 2-deoxyglucose uptake (60-80%) after a 24-h incubation with GH (500 ng/ml), indicating that GH inhibits glucose metabolism specifically at the step of glucose transport. Glucose growth hormone Mus musculus
2 3-O-Methyl-D-glucose uptake was inhibited to an extent similar to that of 2-deoxyglucose uptake (60-80%) after a 24-h incubation with GH (500 ng/ml), indicating that GH inhibits glucose metabolism specifically at the step of glucose transport. Glucose growth hormone Mus musculus
3 These data suggest that GH regulates Glut 1 and Glut 4 transporters differentially and that it exerts its inhibitory effect on glucose uptake at least in part by decreasing the synthesis of Glut 1 transporters. Glucose growth hormone Mus musculus