Title : Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism.

Pub. Date : 2012 Apr 27

PMID : 22541435






1 Functional Relationships(s)
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1 Transcriptome and metabolomic analyses indicate that Kras(G12D) serves a vital role in controlling tumor metabolism through stimulation of glucose uptake and channeling of glucose intermediates into the hexosamine biosynthesis and pentose phosphate pathways (PPP). Pentosephosphates Kirsten rat sarcoma viral oncogene homolog Mus musculus