Title : Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism.

Pub. Date : 2012 Apr 27

PMID : 22541435






2 Functional Relationships(s)
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1 Unlike canonical models, we demonstrate that Kras(G12D) drives glycolysis intermediates into the nonoxidative PPP, thereby decoupling ribose biogenesis from NADP/NADPH-mediated redox control. NADP Kirsten rat sarcoma viral oncogene homolog Mus musculus
2 Unlike canonical models, we demonstrate that Kras(G12D) drives glycolysis intermediates into the nonoxidative PPP, thereby decoupling ribose biogenesis from NADP/NADPH-mediated redox control. NADP Kirsten rat sarcoma viral oncogene homolog Mus musculus