Title : Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma.

Pub. Date : 2012 Jun 14

PMID : 22538852






2 Functional Relationships(s)
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1 In this study, we examined whether IRE1alpha-XBP1 pathway is a potential therapeutic target in MM using a small-molecule IRE1alpha endoribonuclease domain inhibitor MKC-3946. MKC3946 X-box binding protein 1 Homo sapiens
2 Finally, MKC-3946 inhibited XBP1 splicing in a model of ER stress in vivo, associated with significant growth inhibition of MM cells. MKC3946 X-box binding protein 1 Homo sapiens