Title : Characterisation of von Willebrand factor A1 domain mutants I1416N and I1416T: correlation of clinical phenotype with flow-based platelet adhesion.

Pub. Date : 2012 Jul

PMID : 22537243






1 Functional Relationships(s)
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1 Impairment of GPIbalpha binding was more marked for I1416N rVWF than I1416T under both static and flow conditions: this was in spite of similar VWF:Ristocetin cofactor (RCo) activities in patient plasma and is consistent with a respective clinical phenotype. Ristocetin glycoprotein Ib platelet subunit alpha Homo sapiens