Title : Regional- and agonist-dependent facilitation of human neurogastrointestinal functions by motilin receptor agonists.

Pub. Date : 2012 Oct

PMID : 22537158






2 Functional Relationships(s)
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1 Motilin 1-300 nM and the selective motilin agonist GSK962040 0.1-30 microM acted pre-junctionally to strongly facilitate cholinergic contractions of the antrum (E(max) 1000% for motilin), with smaller increases in fundus, duodenum and ileum; high concentrations increased baseline muscle tension in fundus and small intestine. N-(3-fluorophenyl)-1-((4-(((3S)-3-methyl-1-piperazinyl)methyl)phenyl)acetyl)-4-piperidinamine motilin Homo sapiens
2 Motilin 1-300 nM and the selective motilin agonist GSK962040 0.1-30 microM acted pre-junctionally to strongly facilitate cholinergic contractions of the antrum (E(max) 1000% for motilin), with smaller increases in fundus, duodenum and ileum; high concentrations increased baseline muscle tension in fundus and small intestine. N-(3-fluorophenyl)-1-((4-(((3S)-3-methyl-1-piperazinyl)methyl)phenyl)acetyl)-4-piperidinamine motilin Homo sapiens