Title : In vitro P-glycoprotein efflux inhibition by atypical antipsychotics is in vivo nicely reflected by pharmacodynamic but less by pharmacokinetic changes.

Pub. Date : 2012 Aug

PMID : 22525746






1 Functional Relationships(s)
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1 RESULTS: In rhodamine 123 efflux assay drugs inhibitory potency to P-gp could be ranked quetiapine>N-desmethylclozapine>clozapine>olanzapine. Rhodamines phosphoglycolate phosphatase Mus musculus