Title : Increased endogenous H2S generation by CBS, CSE, and 3MST gene therapy improves ex vivo renovascular relaxation in hyperhomocysteinemia.

Pub. Date : 2012 Jul 1

PMID : 22517358






6 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Endogenously, H(2)S is produced as a metabolite of homocysteine (Hcy) by cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3MST). Homocysteine mercaptopyruvate sulfurtransferase Homo sapiens
2 Endogenously, H(2)S is produced as a metabolite of homocysteine (Hcy) by cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3MST). Homocysteine mercaptopyruvate sulfurtransferase Homo sapiens
3 Endogenously, H(2)S is produced as a metabolite of homocysteine (Hcy) by cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3MST). Homocysteine mercaptopyruvate sulfurtransferase Homo sapiens
4 Endogenously, H(2)S is produced as a metabolite of homocysteine (Hcy) by cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3MST). Homocysteine mercaptopyruvate sulfurtransferase Homo sapiens
5 Ex vivo renal artery culture with CBS, CSE, and 3MST triple gene therapy generated more H(2)S in the presence of Hcy, and these arteries were more responsive to endothelial-dependent vasodilation compared with nontransfected arteries treated with high Hcy. Homocysteine mercaptopyruvate sulfurtransferase Homo sapiens
6 We conclude that conversion of Hcy to H(2)S by CBS, CSE, or 3MST triple gene therapy improves renovascular function in HHcy. Homocysteine mercaptopyruvate sulfurtransferase Homo sapiens