Title : Propylthiouracil-induced hypothyroidism delays apoptosis during the first wave of spermatogenesis.

Pub. Date : 2011

PMID : 22513421






3 Functional Relationships(s)
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1 Neonatally administered PTU promoted a delay in the differentiation of Sertoli cells as evaluated by the expression of clusterin using immunohistochemistry and RT-PCR. Propylthiouracil clusterin Rattus norvegicus
2 Clusterin had different expression levels in control and PTU-treated animals, but under both conditions the highest levels were found in 35-day-old rats. Propylthiouracil clusterin Rattus norvegicus
3 In addition, clusterin displayed a cytoplasmic localization in control testes, but appeared located in the nucleus in PTU-treated animals. Propylthiouracil clusterin Rattus norvegicus