Title : Antagonist-mediated down-regulation of Toll-like receptors increases the prevalence of human papillomavirus infection in systemic lupus erythematosus.

Pub. Date : 2012 Apr 18

PMID : 22513098






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Independent explanatory variables associated with down-regulation of TLR7 level included HPV infection and a higher cumulative dose of prednisolone; while a higher cumulative dose of hydroxychloroquine and HPV infection were associated with down-regulation of TLR9 level. Hydroxychloroquine toll like receptor 9 Homo sapiens
2 CONCLUSIONS: In conclusion, prednisolone and TLR antagonist (hydroxychloroquine) may down-regulate protein levels of TLR7 and TLR9 in lupus patients, thereby decreasing the innate immune response against HPV infection. Hydroxychloroquine toll like receptor 9 Homo sapiens