Pub. Date : 2012
PMID : 22511970
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We therefore propose that lipopolysacharides (LPS) may stimulate CD14 production in liver cells and promote the removal of endotoxins. | lps | CD14 molecule | Rattus norvegicus |
| 2 | The aims of this study are to test the hypothesis that CD14 is upregulated by LPS and investigate the pathophysiological role of CD14 production during cholestasis. | lps | CD14 molecule | Rattus norvegicus |
| 3 | Using Western blotting, qRT-PCR, and promoter activity assay, we demonstrated that LPS was associated with a significant increase in CD14 and MD2 protein and mRNA expression and CD14 promoter activity in C9 rat hepatocytes but not in the HSC-T6 hepatic stellate cell line in vitro. | lps | CD14 molecule | Rattus norvegicus |
| 4 | Using Western blotting, qRT-PCR, and promoter activity assay, we demonstrated that LPS was associated with a significant increase in CD14 and MD2 protein and mRNA expression and CD14 promoter activity in C9 rat hepatocytes but not in the HSC-T6 hepatic stellate cell line in vitro. | lps | CD14 molecule | Rattus norvegicus |
| 5 | CD14 expression and endotoxin levels were found to significantly increase after LPS administration in BDL rats. | lps | CD14 molecule | Rattus norvegicus |
| 6 | In conclusion, cholestasis and LPS stimulation were here found to upregulate hepatic CD14 expression, which may have led to increased endotoxin sensitivity and host proinflammatory reactions, causing organ failure and death in BDL rats. | lps | CD14 molecule | Rattus norvegicus |