Title : Chalcone-based small-molecule inhibitors attenuate malignant phenotype via targeting deubiquitinating enzymes.

Pub. Date : 2012 May 1

PMID : 22510564






1 Functional Relationships(s)
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Protein Name
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1 These chalcone-derivatives directly suppress activity of DUB UCH-L1, UCH-L3, USP2, USP5 and USP8, which are known to regulate the turnover and stability of key regulators of cell survival and proliferation. Chalcone ubiquitin C-terminal hydrolase L3 Homo sapiens