Title : The signaling mechanisms mediating the inhibitory effect of TCH-1116 on formyl peptide-stimulated superoxide anion generation in neutrophils.

Pub. Date : 2012 May 5

PMID : 22510297






2 Functional Relationships(s)
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1 The interaction of p47(phox) with PKC (protein kinase C) isoforms (alpha, betaI, betaII, delta and zeta) was attenuated by TCH-1116, whereas TCH-1116 did not affect the PKC isoforms membrane translocation, phosphorylation (Ser660) and kinase activity. thiocarbohydrazide NSFL1 cofactor Rattus norvegicus
2 The interaction of p47(phox) with PKC (protein kinase C) isoforms (alpha, betaI, betaII, delta and zeta) was attenuated by TCH-1116, whereas TCH-1116 did not affect the PKC isoforms membrane translocation, phosphorylation (Ser660) and kinase activity. thiocarbohydrazide NSFL1 cofactor Rattus norvegicus