Pub. Date : 2013 Mar
PMID : 22508334
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | 1,25-Dihydroxyvitamin D3 inhibits the cytokine-induced secretion of MCP-1 and reduces monocyte recruitment by human preadipocytes. | Calcitriol | C-C motif chemokine ligand 2 | Homo sapiens |
| 2 | Pretreatment with 1,25(OH)2D3 (10 nM and 100 nM) significantly decreased the stimulatory effects of MC medium, TNFalpha and IL-1beta on MCP-1 expression and protein release, although the effect on stimulated release of IL-6 was less potent. | Calcitriol | C-C motif chemokine ligand 2 | Homo sapiens |
| 3 | CONCLUSIONS: These results demonstrate that 1,25(OH)2D3 decreases the production of MCP-1 and other proinflammatory mediators by preadipocytes and reduces monocyte migration. | Calcitriol | C-C motif chemokine ligand 2 | Homo sapiens |