Title : Histone H2B ubiquitylation promotes activity of the intact Set1 histone methyltransferase complex in fission yeast.

Pub. Date : 2012 Jun 1

PMID : 22505722






3 Functional Relationships(s)
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1 The mechanism of this "trans-histone" modification pathway remains uncertain, and studies carried out in different experimental systems have suggested that H2Bub1 could either influence the subunit composition of methyltransferase complexes or directly stimulate methyltransferase activity. trans-histone H2B clustered histone 21 Homo sapiens
2 Our data argue that trans-histone crosstalk in S. pombe involves direct enhancement of Set1C methyltransferase activity by H2Bub1 and suggest that this represents a conserved aspect of H2Bub1-H3K4me crosstalk in eukaryotes. trans-histone H2B clustered histone 21 Homo sapiens
3 Our data argue that trans-histone crosstalk in S. pombe involves direct enhancement of Set1C methyltransferase activity by H2Bub1 and suggest that this represents a conserved aspect of H2Bub1-H3K4me crosstalk in eukaryotes. trans-histone H2B clustered histone 21 Homo sapiens