Title : High glucose concentrations induce TNF-α production through the down-regulation of CD33 in primary human monocytes.

Pub. Date : 2012 Apr 14

PMID : 22500980






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 High glucose concentrations induce TNF-alpha production through the down-regulation of CD33 in primary human monocytes. Glucose CD33 molecule Homo sapiens
2 Under high glucose conditions, CD33 protein and mRNA expression was significantly decreased, whereas spontaneous TNF-alpha secretion and SOCS-3 mRNA expression were increased in monocytes from healthy donors. Glucose CD33 molecule Homo sapiens
3 Furthermore, the down-regulation of CD33 and increase in TNF-alpha production were prevented when monocytes were treated with the antioxidant alpha-tocopherol and cultured under high glucose conditions. Glucose CD33 molecule Homo sapiens